Millennium Health Pharmacogenetic Testing

Millennium PGTSM is a non-invasive genetic test utilizing an oral swab to identify how a patient’s genetic profile may impact his or her response to certain medications. Two patients, with the same diagnosis and prescribed the same medication and dose, may exhibit significantly different clinical responses.

The information from the test may provide health care providers a faster and more effective path to optimal medication management, helping to maximize the benefits of drug therapy while minimizing the economic, physical, and emotional burdens of ineffective medication trials.

How it Works

Collect Sample

A swab is used to collect a DNA sample from oral fluid

Run Test

Our specialty lab performs genetic testing on the specimen

MAPP® Report

The DNA is analyzed and a report is generated with results interpretation

Clinical Support

Pharmacists and genetic scientists are available for clinical guidance

Genes and Medications

Millennium PGTSM analyzes clinically relevant genetic variants for 14 genes related to medication response to help clinicians individualize prescribing decisions. The Millennium Analysis of Patient Phenotype (MAPP) Report provides clinicians with evidence based and clinically actionable information to support medication decisions for over 40 commonly prescribed medications across 12 medication classes.

12 Medication Classes

Addiction Therapy
Anticoagulants
Anticonvulsants
Antidepressants, SSRIs/SNRIs
Antidepressants, TCAs
Antipsychotics		ADHD Therapy
Benzodiazepines
Muscle Relaxants
NSAIDs
Opioids
Platelet Inhibitors

14 Genes

COMT
CYP2B6
CYP2C19
CYP2C9
CYP2D6
CYP3A4
CYP3A5		DRD2
HLA-B
HTR2C
MTHFR
OPRM1
UGT2B15
VKORC1

Millennium PGT MAPP Report – It’s as easy as 1-2-3!

The Millennium Analysis of Patient Phenotype (MAPP) Report provides clinicians with evidence-based and clinically actionable genetic information to support medication decisions. It can be broken down into three main sections:

1. Laboratory Test Results:
Indicates which gene tests were ordered and the corresponding test results.

2. Current Medication Summary:
An interpretation of your patient’s genetic test results as it relates to his/her current reported medications, highlighting medication(s) that may need attention, and relevant CYP450 drug-drug interactions.

3. Medication Selection Guide:
An objective tool that can be used to inform prescribing decisions according to the patient’s genetic test results.

Attention Needed

Identifies medications that may have a high clinical impact based on the patient’s genetic test results.

Caution

Identifies medications that may have moderate clinical impact based on the patient’s genetic test results.

Minimal Impact

Identifies medications in which the patient is likely to have a typical response based on patient’s genetic test results.

Potential Benefit

Identifies medications for which the patient is likely to have an improved or enhanced response based on patient’s genetic test results.

Drug-Drug Interaction

Identifies potential cytochrome P450 interactions based on patient’s reported medications.

Pharmacogenetics Results Integrated with UDT RADAR® Report

Millennium PGT results are integrated with Millennium UDT results to enhance medication monitoring.

Testimonials

Brian suffered from depression for 25 years, and just like many other mental health patients, he was prescribed many medications that were ineffective. Looking for new therapies to combat his illness, he found Dr. Edgar Castillo-Armas, a clinician who has gone beyond the trial and error approach.

After Samantha suffered a fractured femur, her physician suggested pharmacogenetic testing (PGT) helped manage her pain and prescribe the right medication at the right time. Like many patients, Samantha was caught in the trial-and-error approach to prescribing medication, continuing to respond negatively to prescription medications.

Pharmacogenetic testing helped Lisa’s physician prescribe the right pain medication at the right time. Too many patients rely on medication trial and error – prescribing medicine and observing patient response. As Lisa attempted to manage her pain with ineffective medication, her physician suggested Millennium PGT to predict Lisa’s likely response to a variety of prescription medications.

How to Order


Millennium Health, LLC tests were developed and their performance characteristics determined by Millennium Health. These tests have not been cleared or approved by the US Food and Drug Administration. FDA clearance or approval is not required for clinical use. Millennium Health is regulated under CLIA as qualified to perform high-complexity testing, and is accredited by the College of American Pathologists (CAP). These tests are used for clinical purposes and should not be regarded as investigational or for research. The test results should be used with other clinical and diagnostic findings for patient case management.