Oral Fluid Drug Testing

Medication Monitoring with Oral Fluid Drug Testing

Oral fluid testing (OFT) is a convenient alternative to urine drug testing (UDT). The clinical comparability of UDT with OFT has been shown in several studies,1,2 including a key study published by West et al.3 The Substance Abuse and Mental Health Services Administration (SAMHSA) has endorsed OFT for use in a variety of clinical settings.

Advantages of OFT include:

  • Convenient-no restroom needed
  • Specimen collection observed, mitigating tampering
  • Helpful for patients unable to provide a urine specimen (e.g., in renal failure or due to incontinence)
  • Oral fluid collection may be more acceptable to staff and patients

Collecting and Shipping an Oral Fluid Specimen Is Simple and Convenient

Preparation & Collection

Open the Quantisal™ oral fluid collection device packaging

Hold the collection wand handle & position the cotton pad under the patient’s tongue

The Quantisal volume adequacy indicator turns blue to indicate the collection is finished (4-7 minutes)

Securing & Shipping the Specimen

Put the collection wand into transport tube & secure the red cap

Affix the specimen ID label to the transport tube

Send the specimen to Millennium Health within 2 days post collection

Millennium Health requires the use of a Quantisal™ Oral Fluid Collection Device. This is distributed by our e-commerce supplier, American Solutions for Business (ASB). The content above is only intended as a quick reference and does not replace the ‘Instructions for Use’ supplied by the device manufacturer and the Millennium Health Medication Monitoring Specimen Collection, Ordering and Shipping Manual.


  1. V. Vindenes, et al. Oral Fluid is a Viable Alternative for Monitoring Drug Abuse: Detection of Drugs in Oral Fluid by Liquid Chromatography-Tandem Mass Spectrometry and Comparison to the Results from Urine Samples from Patients Treated with Methadone or Buprenorphine. J. Anal. Toxicol. 2011, 35:32-39.
  2. C. Moore, D. Crouch. Oral Fluid for the detection of drugs of abuse using immunoassay and LC-MS/MS. Bioanalysis (2013) 2(12), 1555-1569.
  3. West R, Mikel C, Hofilena D, Guevara M. Positivity rates of drugs in patients treated for opioid dependence with buprenorphine: A comparison of oral fluid and urine using paired collections and LC-MS/MS. Drug Alcohol Depend. 2018, 193:183-191.

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